Table 3.
MSGB differentiates multicase families from sporadic families
| Components used in computing MSGB median (P25-P75) |
Multicase families probands n=403 |
Sporadic families probands n=810 |
Multicase families parents n=522 |
Sporadic families parents n=1161 |
Spouses as unrelated controls n=250 |
Cuzick’s Test P-value |
|---|---|---|---|---|---|---|
| Gender + HLA + non-MHC SNPs | 4.57 (3.95–5.13) | 4.38 (3.81–4.96) | 4.12 (3.63–4.65) | 3.96 (3.56–4.52) | 3.65 (3.28–4.08) | z=−20.56 p<10−16 |
| HLA + non-MHC SNPs | 4.28 (3.61–4.70) | 4.01 (3.46–4.59) | 3.78 (3.43–4.48) | 3.69 (3.34–4.31) | 3.49 (3.18–3.92) | z=−12.02 p<10−16 |
| Gender + non- MHC SNPs | 3.86 (3.55–4.15) | 3.83 (3.55–4.11) | 3.67 (3.41–3.98) | 3.66 (3.35–3.97) | 3.45 (3.17–3.76) | z=−20.30 p<10−16 |
| Non-MHC SNPs only | 3.48 (3.24–3.70) | 3.46 (3.20–3.73) | 3.47 (3.18–3.67) | 3.41 (3.16–3.66) | 3.35 (3.10–3.60) | z=−5.25 p= 1.5e-07 |
Table 3 presents medians and inter-quartile ranges (P25-P75) of the Multiple Sclerosis Genetic Burden (MSGB) in probands, parents, and controls. For each row, the MSGB is computed using the components in the first column. HLA stands for the HLA-DRB1*15:01 allele. The significance of the observed non parametric gradient from probands to controls through parents differentiating members of multi-case MS sporadic MS is assessed using a two-sided Cuzick’s test whose statistics; test’s statistics and p-values are given in the last column.