Skip to main content
. Author manuscript; available in PMC: 2012 Dec 3.
Published in final edited form as: Circulation. 2011 Jul 18;124(5):10.1161/CIRCULATIONAHA.110.005108. doi: 10.1161/CIRCULATIONAHA.110.005108

Figure 7. Shear stress regulation of KLF2.

Figure 7

The diagram shows the regulatory circuitry of the responses of transcription factors and miRNAs to atheroprotective shear flow. The circled numerals refer to the Table numbers. Shear stress with a forward direction regulates the expressions of KLF2 and miR-92a through several TFs (in Supplemental Tables 2 and 3, respectively). Serving as a transcription factor, KLF2 transactivates the expression of downstream genes such as eNOS and TM. In addition, KLF2 may bind to the promoter region of some miRNAs, including miR-126, to upregulate their transcription directly (Supplemental Table 4). In turn, the network of KLF2 and miRNAs regulates the expression of factors that control anti-inflammatory, anti-thrombotic, anti-proliferative, anti-angiogenic, anti-oxidant, and anti-fibrotic effects to maintain EC functions. The methods for computational analysis are described in the supplements.