Skip to main content
. Author manuscript; available in PMC: 2014 Jan 18.
Published in final edited form as: Chem Rev. 2012 Jul 18;112(12):6353–6372. doi: 10.1021/cr3001077

Figure 10.

Figure 10

A). Schematic diagram of the arrangement of the α, β and γ subunits of ENaC. Each ENaC subunit consists of a short N and C-termini, and an extensive extracellular loop. The C-terminus contains a PPXY motif that interacts with the Nedd-4 WW domains. See text for details. B). ENaC is localized to the apical membrane. Loss-of-function mutations result in non-functional ENaCs either being mistrafficked, or unable to conduct. These mutations lead to impaired Na+ transport. C). Gain-of-function mutations are a result of mutations to the binding site of Nedd-4, a protein required for the ubiqination of ENaC, leading to an accumulation of ENaC, and increased Na+ cellular absorption.