Table 1.

Variants Responsible for the Associations Detected by GWASs

Phenotype	Gene	Causal Variants		GWAS Variants		References
		Name	MAF	Name	MAF
Crohn disease	NOD2	rs2066844	4.1%	rs17221417	28.7%	Wang et al.4
		rs2066845	1.5%
		rs2066847	1.9%
Ribavirin-induced hemolytic anemia	ITPA	rs1127354	7.6%	rs6051702	19.4%	Fellay et al.5
		rs7270101	12.3%
Therapeutic warfarin dose	CYP2C9	rs1799853	11%	rs4917639	18%	Takeuchi et al.9 and Wadelius et al.10
		rs1057910	7%
Bladder cancer	UGT1A6	rs17863783	2.5%	rs11892031	8.5%	Tang et al.11
Low-density lipoprotein cholesterol	PCSK9	rs11591147	3.7%	rs11206510	24.3%	Sanna et al.8
Sick sinus syndrome	MYH6	c.2161C>Ta	0.38%	rs28730774	1%	Holm et al.6
Ovarian cancer	BRIP1	c.2040_2041insTTb	0.41%	rs34289250	0.89%	Rafnar et al.7

The following abbreviations are used: GWAS, genome-wide association study; and MAF, minor allele frequency.

^aRefSeq NM_002471.3; reference genome build 36.

^bRefSeq NM_032043.2; reference genome build 36.