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Winchester Mutation Reduces Protein Stability
Transient transfections in COS-7 cells were performed with expression constructs for WT MT1-MMP and Winchester altered MT1-MMP.
(A) Increased protein turnover in Winchester MT1-MMP-transfected cells (40 μg) incubated with 50 μg/ml cycloheximide (CHX).
(B) MG-132 treatment increases levels of the proenzyme form of MT1-MMP, but not of the active form in Winchester MT1-MMP-transfected cells (30 μg).
