Fig. 5.

Deletion mutants showed changes in adipokines. The statistical analysis was done by one-way ANOVA followed by Newman-Keuls and Bonferroni's multiple comparison tests. A, The 22 deletion mutant females showed higher levels of adiponectin (P < 0.0001) when compared with controls (n = 18). Furthermore, both groups of females expressed higher adiponectin than males (P < 0.0001). Deletion mutant males (n = 17) showed higher levels of adiponectin than controls (n = 16, unpaired t test with Welch's correction, P = 0.0064). B, Higher levels of serum resistin in both groups of deletion mutants are shown (males, unpaired Student's t test with Welch's correction, P = 0.034, n = 40 controls, 44 mutants; females, ANOVA followed by Newman-Keuls, P = 0.0004, n = 40 controls and 45 mutants). C Serum GIP is higher only in males (Bonferroni's P = 0.0179, n = 26 control and 27 mutant males; 26 control and 32 mutant females). D, The proinflammatory IL-6 is lower in deletion mutant females (Newman-Keuls, P = 0.03) than controls, but values in deletion mutant males and controls are not different (n = 35 control males, 50 deletion mutant males, 24 control females, 34 deletion mutant females). *, Significantly different from controls; °, significantly different from male groups.