Fig. 2.
The Kaplan-Meier survival curves for the ThrbPV/+ mice and WT siblings with or without treatment with PTU for the observation period of 12 months. PTU treatment started at the ages of 2–3 months and continued for 12 months. The Kaplan-Meier cumulative survival analysis was performed using GraphPad Prism version 5.0. No deaths occurred for WT mice (n = 17) or untreated ThrbPV/+ mice (n = 12) during the observation period. Only three WT-PTU mice died (n = 19; three of 19, 16%) during the observation period. In contrast, all the ThrbPV/+-PTU mice (n = 14) died by 12 months of age. Percent survival of WT-PTU and ThrbPV/+-PTU mice differed significantly (P < 0.05) as determined by a Mantel-Cox test.