Table 1.
Thyroid pathological features of WT-PTU and Thrb PV/+-PTU mice
| Pathological features | Hyperplasia | Capsular invasion | Vascular invasion | Anaplasia | Lung mets |
|---|---|---|---|---|---|
| WT-PTU | 19/19 (100%) | 3/19 (16%) | 0/19 (0%) | 0/19 (0%) | 0/19 (0%) |
| ThrbPV/+-PTU | 9/9 (100%) | 8/9 (89%) | 4/9 (44%) | 1/9 (11%) | 3/9 (33%) |
WT-PTU (n = 19) and ThrbPV/+-PTU (n = 9) mice were treated with PTU for 12 months. Sections of thyroids and lungs were stained with H & E and analyzed for pathological progression of hyperplasia, capsular invasion, vascular invasion, anaplasia, and metastases in the lung and heart. Mets, metastases.