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. 2012 Aug 14;153(10):4830–4837. doi: 10.1210/en.2012-1601

Fig. 4.

Fig. 4.

Antiinflammatory treatment prevents chronic stress-induced increases in GFAP in the medial prefrontal cortex of stress-sensitive CRF2−/− mice. A–F, Representative immunofluorescence images (×20 magnification) of GFAP (red) counterstained with DAPI (nuclei, blue) in the medial prefrontal cortex (mPFC) of WT (A–C) and CRF2−/− (D--F) mice for control (A and D), after exposure to CVS (B and E), or CVS + NSAID (C and F). G, Bar graph illustrates semiquantitative analysis of GFAP immunofluorescence showing significantly elevated levels in the mPFC after CVS in CRF2−/− mice. Concomitant treatment with NSAID rescued this effect. H, Atlas image illustrating the brain section used for analysis, adapted from the mouse atlas (26). Data are presented as parameter estimates of the best-fit model + observed sd of respective groups (n = 3–4). *, P < 0.05.