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Induction of p300 expression by cortisol in human amnion fibroblasts. A, Dose-dependent induction of p300 mRNA by cortisol. B, Comparison of induction of P300 by cortisol (1 μm) in the presence and absence of RU486 (1 μm). C, Dose-dependent induction of p300 protein by cortisol and the attenuation by RU486. The upper panel is the representative Western blot and the bottom panel is the mean data (n = 3–4). *, P < 0.05, **, P < 0.01, ***, P < 0.001 vs. vehicle control.
