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. Author manuscript; available in PMC: 2012 Dec 3.
Published in final edited form as: J Immunol. 2011 Jul 8;187(4):1617–1625. doi: 10.4049/jimmunol.1000815

Figure 3. Human tumor cells expressing either IDO through transfection or in response to IFN-γ express a BCH resistant tryptophan transporter.

Figure 3

Measurement of transporter-mediated 3H-L-tryptophan uptake was measured under initial rate conditions over 3 min. Hela cells were cultured for 48h before the assay and tryptophan uptake by IDO-lentivirus transduced or IFN-γ treated Hela cells was measured in the presence of a panel of System L and LAT inhibitors including: A. BCH, B. D-Met and C. L-Met. Plotted data are normalized and are the means of triplicate measurements ± SE. Statistical significance <0.05 as assessed using Student’s T-test is indicated by *. Data are representative of at least three independent experiments.