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. 2012 Dec 3;2:916. doi: 10.1038/srep00916

Figure 7. Schematic presentation of the signaling pathway involved in histamine-induced up-regulation of H1R mRNA expression in HeLa cells.

Figure 7

Binding of histamine to H1R activates PKCδ and translocates PKCδ from the cytosol to the Golgi apparatus, where PKCδ phosphorylates MEK and ERK. Phosphorylated ERK then activates PARP-1. Activated PARP-1 PARylates Ku86 and induces dissociation of Ku86 from region B1 of the promoter, which activates H1R gene transcription. Activated PARP-1 also PARylates histone and induces decondensation of the chromatin structure, enhances the binding of Ets-1 and AP-1 transcription factors to region A of the promoter, which activates H1R gene transcription.