Table 3 . McDonald–Kreitman test on candidate genes.

	Two-species MK testa		mel MK testb
Gene	No. codons	P-value	No. codons	P-value
AGO3	NA	NAc	689	0.351
armi	1186	<0.001	1231	<0.001
aub	835	<0.001	855	<0.001
Hen1	389	0.837	391	1.000
Hrb27C	421	0.095	421	0.532
Irbp	628	0.189	628	0.069
krimp	712	0.020	690	0.001
Ku80	694	0.012	699	0.156
mael	NA	NA	459	0.390
piwi	837	0.732	843	0.267
Psi	796	0.189	797	1.000
rhi	413	0.396	413	0.535
spn-E	1427	0.021	1433	0.731
squ	130	0.493	233	1.000
vas	634	0.022	639	0.151
zuc	253	1.000	253	1.000

MK tests with significant p-values and positive α are in bold type.

^aMK tests using both D. melanogaster and D. simulans polymorphism (see Materials and Methods).

^bMK tests using only D. melanogaster polymorphism.

^cNot available due to lack of D. simulans polymorphism data.