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. Author manuscript; available in PMC: 2012 Dec 3.
Published in final edited form as: Am J Physiol Cell Physiol. 2011 Jul 13;301(4):C872–C885. doi: 10.1152/ajpcell.00507.2010

Fig. 1.

Fig. 1

Rescue of F508del-CFTR function by corr-4a and low temperature. Transepithelial Cl− currents were measured in CFBE41o- cells expressing F508del or wild type CFTR. A: representative recordings showing response of F508del-CFTR to acute application of CPT-cAMP (200 μM), felodipine (5 μM), and inh-172 (10 μM). Cells were kept for 24 hours under control conditions or treated with corr-4a (C4, 5 μM) and/or low temperature (27 °C). B: representative experiments from cells expressing wild type CFTR. CFTRinh-172 was applied after or before (red trace) stimulation with CPT-cAMP plus felodipine. C: summary of data from transepithelial Cl− current experiments. Total CFTR activity was evaluated by measuring the amplitude of the current inhibited by inh-172 (n = 19-29; **, p < 0.01).