Table 3.
IDH1 mutations and outcomes in acute myeloid leukemia
| Author [ref.] | IDH1 status | N | CR (%) | P-value | HR for OS | 95% CI for OS |
|---|---|---|---|---|---|---|
| Patel [44] | IDH1 wild type | 372 | NR | 1.00 | Reference | |
| IDH1 Mutation | 23 | NR | 0.86 | 0.52-1.43 | ||
| Zhang [42] | IDH1 wild type | 194 | 65.5% | NS | NR | NR |
| IDH1 Mutation | 15 | 66.70% | NR | NR | ||
| Choua [31] | IDH1 wild type | 287 | 73.60% | NR | NR | NR |
| IDH1 Mutation | 22 | 86.44% | NR | NR | ||
| Schnittger [39] | IDH1 wild type | 717 | NR | 1.00 | Reference | |
| IDH1 Mutation | 52 | NR | 1.36 | 0.93-1.97 | ||
| Abbas [17] | IDH wild type | 694 | NR | 1.00 | Reference | |
| IDH1 Mutation | 49 | NR | 1.09 | 0.76-1.58 | ||
| Paschka [20] | IDH wild type | 607 | NR | 1.00 | Reference | |
| IDH1 Mutation | NA | NR | 1.42 | 1.03-1.99 | ||
| Ho [15] | IDH1 wild type | 262 | 51% | 0.14 | 1.00 | Reference |
| IDH1 Mutation | 12 | 75% | 0.90 | 0.48-1.71 | ||
| Chou [14] | IDH1 wild type | 466 | NR | 1.00 | Reference | |
| IDH1 Mutation | 27 | NR | 0.82 | 0.38-1.78 | ||
| Ward [11] | IDH1 wild type | 72 | NR | 1.00 | Reference | |
| IDH1 Mutation | 6 | NR | 1.60 | 0.57-4.45 | ||
| Green [16] | IDH1 wild type | 1226 | 83% | NR | 1.00 | Reference |
| IDH1 Mutation | 107 | 81% | 1.06 | 0.79-1.40 | ||
| Mardis [6] | IDH1 wild type | 172 | NR | 1.00 | Reference | |
| IDH1 Mutation | 16 | NR | 1.72 | 0.98-3.01 |
CR, complete remission; HR, hazard ratio; 95% CI, 95% confidence interval; OS, overall survival; NS, not significant; NA, not assessed; NR, not reported.
a
For the Abbas and Paschka studies, AML patients younger than 60 years were used for survival analysis.