Table 4.
IDH1 mutations and outcomes in cytogenetically normal acute myeloid leukemia
| Author [ref.] | IDH1 status | N | CR (%) | P-value | HR for OS | 95% CI for OS |
|---|---|---|---|---|---|---|
| Ravandi [43] | IDH1 wild type | 93 | NR | 1.00 | Reference | |
| IDH1 Mutation | 11 | NR | 0.59 | 0.24-1.44 | ||
| Shen [41] | IDH1 wild type | 506 | 61.30% | 0.223 | NR | NR |
| IDH1 Mutation | 52 | 51.90% | NR | NR | ||
| Abbas [17] | IDH wild type | 268 | NR | 1.00 | Reference | |
| IDH1 Mutation | 35 | NR | 1.19 | 0.64-2.22 | ||
| Green [16] | IDH wild type | 468 | NR | 1.00 | Reference | |
| IDH1 Mutation | 60 | NR | 1.06 | 0.75-1.49 | ||
| Boissel [18] | IDH1 wild type | 179 | 86% | 0.19 | 1.00 | Reference |
| IDH1 Mutation | 34 | 76% | 0.95 | 0.58-1.54 | ||
| Marcucci [19] | IDH wild type | 240 | 75% | 0.86 | 1.00 | Reference |
| IDH1 Mutation | 49 | 73% | 1.20 | 0.83-1.73 | ||
| Wagner [40] | IDH1 wild type | 245 | 80% | 0.097 | 1.00 | Reference |
| IDH1 Mutation | 30 | 67% | 1.19 | 0.72-1.96 | ||
| Mardis [6] | IDH1 wild type | 67 | NR | 1.00 | Reference | |
| IDH1 Mutation | 13 | NR | 1.18 | 0.61-2.27 |
CR, complete remission; HR, hazard ratio; 95% CI, 95% confidence interval; OS, overall survival; NR, not reported.