Table 2.
Genes showing aberrant expression in primary and/or advanced PCa compared to normal prostate. The selected genes are not all-inclusive, rather, they represent genes that were found in multiple DNA microarray or meta-analysis studies
| Pathway or cellular function | Gene name | Gene symbol | Expression | REF |
|---|---|---|---|---|
| Cell cycle, cell proliferation | cellular-Myelocytomatosis viral oncogene | C-Myc | Up | [188,190,193,261] |
| Cyclin dependent kinase 1, 10 | CDK1, 10 | Up | ||
| DNA topoisomerase 2A | TOP2A | Up | ||
| Myb-related protein B | MYBL2 | Up | ||
| Androgen receptor | AR | Up | ||
| Estrogen receptor 1 | ESR1 | Up | ||
| Extracellular matrix, cell migration, cell adhesion | Tumor-associated calcium signal transducer 1 | TACSTD1 | Down | [188,191,192,197] |
| Cadherin-1 | CDH-1 | Down | ||
| Hyaluronan-mediated motility receptor | HMMR | Down | ||
| Metalloproteinase inhibitor 3 | TIMP3 | Up | ||
| Matric metalloprotease 9 | MMP9 | Up | ||
| Fatty acid, androgen, other metabolism | Alpha-methylacyl-CoA racemase | AMACR | Up | [195,200,201] |
| Fatty acid synthase | FASN | Up | ||
| Ornithine decarboxylase | ODC | Up | ||
| Signal transduction, transcription | Transcription factor E2F1 | E2F1 | Up | [190,194,196,198] |
| Type I inositol-3,4-bisphosphate 4-phosphatase | INPP4A | Up | ||
| Mitogen activated protein kinase | MAPK | Up | ||
| Histone-lysine N-methyltransferase | EZH2 | Up | ||
| c-Fos | FOS | Up | ||
| Forkhead box protein M1 | FOXM1 | Up | ||
| Ubiquitin carboxyl-terminal hydrolase 13 | USP-13 | Up | ||
| Transcription factor jun-B | JUNB | Up | ||
| Nuclear factor-κB | NFκB | Up | ||
| Signal transducers & activators of transcription 6 | STAT6 | Up | ||
| Homeobox protein NKX3.1 | NKX3.1 | Up | ||
| Function unknown | Hepsin | HPN | Up | [188,190,191,193,196,200] |