Table 2.

Change of JKOM score during study period.

		Time (month)
		0	2	4	6	12
Total	HA	100.0 ± 0.0	80.6 ± 3.1*	71.8 ± 3.0*	72.4 ± 3.5*	70.9 ± 3.9*
	Placebo	100.0 ± 0.0	87.4 ± 3.1*	78.9 ± 3.1*	74.8 ± 3.2*	72.1 ± 4.0*
Subscale
Pain and stiffness in knees	HA	100.0 ± 0.0	77.0 ± 3.6*	70.2 ± 3.7*	73.7 ± 4.2*	66.8 ± 4.4*
	Placebo	100.0 ± 0.0	84.6 ± 4.6*	76.5 ± 3.9*	71.8 ± 4.0*	72.5 ± 8.0*
Condition in daily life	HA	100.0 ± 0.0	83.7 ± 3.8*	77.6 ± 3.9*	77.0 ± 4.1*	76.2 ± 4.4*
	Placebo	100.0 ± 0.0	89.2 ± 3.7*	83.9 ± 4.1*	81.3 ± 3.5*	76.0 ± 3.4*
General activities	HA	100.0 ± 0.0	94.2 ± 7.4	75.5 ± 4.8*	73.3 ± 5.0*	81.1 ± 5.8*
	Placebo	100.0 ± 0.0	92.5 ± 4.9	80.3 ± 5.8*	73.4 ± 4.8*	72.8 ± 4.1*
Health condition	HA	100.0 ± 0.0	74.0 ± 6.0∗#	64.6 ± 7.7∗#	63.0 ± 6.1∗#	60.9 ± 5.6∗#
	Placebo	100.0 ± 0.0	96.1 ± 8.2	91.1 ± 9.9	88.3 ± 10.1*	81.2 ± 6.0*

Results are shown by relative rations (in percent) against scores at baseline. Mean ± SE of 18 (HA group) or 20 (placebo group) subjects are shown.

^∗ P < 0.05 against baseline; ^# P< 0.05 against placebo group.