(a)

ID	Age of the patient at the time of NP event (years)	Interval between NP event and SLE diagnosis (years)	Case definition	Brain CT scan/brain MRI/EMG
1*	16	−2	Generalized seizure disorder, acute psychosis, and severe hemicraneal headache	MRI: generalized cortical atrophy
2	11	0	Generalized seizure disorder	Not available
3*	30	0	Generalized seizure disorder	MRI: multiple focal deep white matter lesions hyperintense in T2-weighted images and FLAIR
4*	17	0	Generalized seizure disorder	MRI: no abnormality
5*	42	−1	Generalized seizure disorder, severe headache, major depression	MRI: subcortical high signal bifrontal, bilateral deep cortical, and corona radiata focal lesions in T2-weighted images.
6*	23	0	Generalized seizure disorder and ischemic stroke	MRI: right cerebral atrophy. Left thalamic calcified lesion.
7	49	0	Ischemic stroke	CT scan: ischemic infarct left hippocampus
8	31	1	Ischemic stroke	CT scan: left lenticular haemorrhagic infarct
9	50	2	Ischemic stroke	MRI: right ischemic parieto-temporal infarct
10	23	0	Peripheral neuropathy	EMG: motor-sensitive neuropathy
11	17	1	Peripheral neuropathy	EMG: motor-sensitive neuropathy
12*	45	0	Major depression, severe hemicraneal headache	MRI: multiple focal deep white matter high signal on T2-weighted images and FLAIR. Small focal lesions in the subcortical fronto parietal white matter, predominantly on the right.
13*	29	2	Major depression with suicidal ideation, cluster headache	MRI: multiple small focal subcortical white matter and right paramedian pontine high-signal lesions on T2-weighted images and FLAIR.

*Interictal EEG was performed in these patients. An epileptiform focus was detected in 3 (patients 3, 4, and 6) with no abnormality in the other 4 patients (patients 1, 5, 12, and 13). Nephritis was present in patients 3, 12, and 13 at the time of the NP event.