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. 2012 Nov 13;13(12):1070–1078. doi: 10.1038/embor.2012.167

Figure 1.

Figure 1

B-type lamins are required for brain development. The genotype of the brain and the brain sections is indicated above the panels. (A) Mice mutant for lamin B have smaller brains; brains are from embryonic day (E)18.5 mouse embryos. (B) Staining of E18.5 neocortex coronal sections of mouse embryos for nucleic acids. Neurons from lamin B-null mice have layer organization and migration defects. (C) Layer-specific labelling of the neocortex with Tbr1 (green) for early-born deep layer (V,VI) and Brn1 (red) for late-born outer neuronal layers (II–IV). DNA is labelled in blue. (D) BrdU (green) labelling of mid-to-late-born neurons from E18.5 mice embryos. The data for this figure have been used with permission from figure 4 in [23]. BrdU, bromodeoxyuridine; Brn1, POU domain, class 3, transcription factor 3; CP, cortical plate; IZ, intermediate zone; MZ, marginal zone; Tbr1, T-box, brain, 1; VZ, ventricular zone.