Table 4.

Gene and haplotype ALI associations in European Ancestry trauma subjects

Gene	N	SNPs	Single SNP p-value	Linear p-value	IBS p-value	Quadratic p-value
NFKBIA block 1	211	4	0.012	0.051	0.077	0.042
VEGFA block 2	211	3	0.016	0.020	0.045	0.0088

Two ALI candidate gene haplotype blocks were significant among EA subjects, in genes NFKBIA and VEGFA. As in Table 3, the results of 3 different kernel functions are shown, and are contrasted with the individual SNP showing the strongest ALI association for the block in question. While the most extreme NFKBIA individual SNP association with ALI was stronger than that detected by kernel function testing, the individual SNP was distinct from ALI – associated variants previously reported for this gene [39]. N: number of subjects with complete data; SNPs: number of SNPs per ALI-associated block.