Table 3. Genotype counts, associations, and odds ratios in patients with high myopia, extreme myopia and pooled control participants.
| SNP | Genotype | Pooled control |
High myopia |
Extreme myopia |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| n | Genotype frequency p value* | Allele frequency p value* | HWE P value | n | Nominal p value† | Adjusted p value‡ | Adjusted odds ratio (95% confidence interval) | n | Nominal p value† | Adjusted p value‡ | Adjusted odds ratio (95% confidence interval) | |||
|
rs2071754 |
CC |
322 |
0.53 |
0.99 |
0.74 |
326 |
0.44 |
0.343 |
1.06 |
196 |
0.327 |
0.317 |
1.07 |
|
| (C/T) |
CT |
622 |
632 |
(0.94–1.18) |
397 |
(0.94–1.21) |
||||||||
| TT |
312 |
344 |
215 |
|||||||||||
|
rs644242 |
CC |
968 |
0.95 |
0.95 |
0.15 |
1052 |
0.0105 |
0.00445 |
0.78 |
651 |
0.0294 |
0.0165 |
0.78 |
|
| (C/A) |
CA |
263 |
237 |
(0.65–0.92) |
149 |
(0.64–0.95) |
||||||||
| AA |
25 |
14 |
8 |
|||||||||||
|
rs3026354 |
AA |
518 |
0.28 |
0.22 |
1 |
544 |
0.99 |
0.834 |
0.99 |
346 |
0.656 |
0.585 |
0.96 |
|
| (A/G) |
AG |
576 |
590 |
(0.88–1.11) |
359 |
(0.84–1.10) |
||||||||
| GG |
160 |
171 |
104 |
|||||||||||
* The difference in genotype and allele frequency between control 1 and control 2 were analyzed using a chi-square test. † Differences in the observed genotypic distribution were examined by chi-square test for trend. ‡ Age and sex adjustment were performed based on a logistic regression model. SNP: Single-nucleotide polymorphism, HWE: Hardy–Weinberg equilibrium