Table 4. Summary of previous reports that evaluated an association between PAX6 and high myopia.

Author (year)	Definition of cases		Cases	Controls	Reported single-nucleotide polymorphisms*			Remarks
	Criteria of high myopia	Affected eye			rs667773‡ rs644242 rs662702	rs3026390 rs3026393 rs2071754	rs3026354 rs628224
Tsai et al., 2008	SE<6 D	Both	255	87	n.s.	-	-	Significant association of AC- and AG-repeat lengths in the P1 promoter
Ng et al., 2009	SE≤6 D	-	379	349	n.s.	-	-
Han et al., 2009	SE<6 D	Both	FBAT† with 164 nuclear family	n.s.	p=0.0011	n.s.		Significant association in haplotype analysis
Liang et al., 2011	SE≤6 D	At least one eye	1083	1096	n.s.	n.s.	n.s.
Jiang et al., 2011	SE≤8 D	Both	300	300	n.s.	n.s.	n.s.
	SE≤8 D	Both	299	299	-	n.s.	-
Current Study	AL≥26 mm	Both	1307	1256	p=0.0045	n.s.	n.s.
Tsai et al., 2008	SE<10 D	Both	67	87	p<0.001	-	-
Liang et al., 2011	SEM≤11 D	At least one eye	55	619	p=0.0074	n.s.	n.s.
Current Study	AL≥28 mm	Both	810	1256	p=0.0165	n.s.	n.s.

* Single-nucleotide polymorphism pairs with r2 ≧ 0.90 in HapMap Phase II are in the same column. † Family-based association test ‡ Although this single-nucleotide polymorphism is not included in HapMap SNP, it is reported to be in strong linkage disequilibrium (r2=0.92) with rs644242. D: diopter, n.s.: Not significant, SE: Spherical equivalent, AL: Axial length.