Table 2.
A118G OPRM1 SNP allele and genotype frequency (n (%)) data in opioid-dependent cases and control groups from individual studies
| Study |
Opioid-dependent cases
|
Control subjects
|
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Allele frequency
|
Genotype frequency
|
Allele frequency
|
Genotype frequency
|
|||||||||
| n | A | G | A/A | A/G | G/G | n | A | G | A/A | A/G | G/G | |
| Bart et al8 | 139 | 235 (84.5) | 43 (15.4) | 98 (70.5) | 39 (28) | 2 (1.5) | 170 | 315 (92.6) | 25 (7.4) | 147 (86.4) | 21 (12.4) | 2 (1.2) |
| Bond et al2 | 111 | 202 (91) | 20 (9) | 92 (83) | 18 (16) | 1 (1) | 39 | 66 (85) | 12 (15) | 29 (74) | 8 (21) | 2 (5) |
| Coller et al (unpublished data) | 53 | 85 (80) | 21 (20) | 37 (70) | 11 (21) | 5 (9) | 80 | 136 (85) | 24 (15) | 57 (71) | 22 (28) | 1 (1) |
| Crettol et al14 | 238 | 411 (86) | 65 (14) | 177 (74) | 57 (24) | 4 (2) | 217 | 376 (87) | 58 (13) | 167 (77) | 42 (19) | 8 (4) |
| Crowley et al11 | 225 | 401 (89) | 49 (11) | 177 (79) | 47 (21) | 1 (0.4) | 200 | 359 (90) | 41 (10) | 161 (81) | 37 (19) | 2 (1) |
| Drakenberg et al1 | 39 | 66 (85) | 12 (15) | 28 (72) | 10 (26) | 1 (3) | 26 | 49 (94) | 3 (6) | 24 (92) | 1 (4) | 1 (4) |
| Franke et al12 | 287 | 498 (87) | 76 (13) | 217 (76) | 64 (22) | 6 (2) | 365 | 642 (88) | 88 (12) | 284 (78) | 74 (20) | 7 (2) |
| Gelernter et al16 | 79 | 143 (91) | 15 (9) | NR | NR | NR | 228 | 400 (88) | 56 (12) | NR | NR | NR |
| Hoehe et al17 | 137 | 263 (96) | 11 (4) | NR | NR | NR | 35 | 67 (96) | 3 (4) | NR | NR | NR |
| Kapur et al13 | 126 | 173 (69) | 79 (31) | 70 (56) | 33 (26) | 23 (18) | 156 | 276 (88) | 36 (12) | 124 (79) | 28 (18) | 4 (3) |
| Li et al18 | 226 | 297 (65) | 155 (34) | 95 (42) | 107 (47) | 24 (11) | 208 | 292 (70) | 124 (30) | 99 (48) | 94 (45) | 15 (7) |
| Luo et al19 | 131 | 240 (92) | 22 (8) | NR | NR | NR | 234 | 416 (89) | 52 (11) | NR | NR | NR |
| Shi et al20 | 145 | 217 (75) | 73 (25) | 85 (59) | 47 (32) | 13 (9) | 48 | 70 (73) | 26 (27) | 26 (54) | 18 (38) | 4 (8) |
| Szeto et al21 | 200 | 242 (61) | 158 (40) | 75 (38) | 92 (46) | 33 (17) | 97 | 137 (71) | 57 (29) | 51 (53) | 35 (36) | 11 (11) |
| Tan et al22 | 97 | 132 (68) | 62 (32) | 47 (48) | 38 (39) | 12 (12) | 404 | 464 (57) | 344 (43) | 128 (32) | 208 (51) | 68 (17) |
| Zhang et al23 | 91 | 158 (87) | 24 (13) | 69 (76) | 20 (22) | 2 (2) | 338 | 589 (87) | 87 (13) | 256 (76) | 78 (23) | 4 (1) |
| Pooled | 3763 | 885 | 1267 | 583 | 127 | 4654 | 1036 | 1553 | 666 | 129 | ||
Abbreviation: NR, not reported.