Table 2.
A new scheme remodeling the HLA-DRB1 shared epitope classification in rheumatoid arthritis
| Allele classification | HLA-DRB1 susceptibility allele | Amino acid sequence | Genetic risk to RA |
|---|---|---|---|
| S2 | *0401 | Q-K-RAA | High |
| S3P | *1303 | D-K-RAA | |
| *0101, *0102, *0404, *0405, *0408 | Q-R-RAA | Intermediate | |
| S1 | *1001, *1402, *1406 | R-R-RAA | |
| *1501, *1502, *1503 | Q-A-RAA | Low | |
| S3D | *0103, *0402, *1102, *1103, *1301, *1302 | D-E-RAA | |
| *1202, *16 | D-R-RAA |
Abbreviations: HLA-DRB1, major histocompatibility complex, class II, DR beta1; RA, rheumatoid arthritis.