Table 2.

Possible role and effects of variations on sulfonylurea treatment goals

	KCNJ11	ABCC8	CYP2C9
Codes	Kir6.2	SUR1	Enzyme in cytochrome P450
Site	KATP channels of pancreas		Liver
Action	SU blocks conductance of KATP channels by interacting with SUR1 and Kir6.2 subunits		Metabolize SU
Variants	Decreased ATP sensitivity and/or pore fixed in the open conformation leading to decreased insulin secretion and subsequent hyperglycemia. Different variations result in different sensitivities to SU	Ser1369Ala variant can influence SU efficacy	Reduced clearance which may correlate to SU toxicity

Abbreviations: ATP, adenosine triphosphate; SU, sulfonylurea.