Table 3.

Possible role and effects of variations on TZD therapy

TZD therapy	ACDC	S447S
	Adiponectin	LPL
Action	Protective, plays role in glucose uptake and fatty acid oxidation. Decrease in adiponectin associated with insulin resistance and atherosclerosis	Hydrolyze triglycerides and mediate clearance of atherogenic lipoproteins
Variants	+45GG allele smaller decreases in FPG level, A1C and increase in adiponectin than those with +45T allele Similarly the +276GG genotype when compared to the +276T allele	S447X shows reduced response