Figure 5.
Schematic of the KATP channel Kir6.2 subunit compositions expected when wild-type (blue) and mutant (red) Kir6.2 are co-expressed in the heterozygous state. If the co-assembly wild-type (blue) and mutant (red) Kir6.2 subunits is independent and random and follows a binomial distribution, as a single KATP channel is made of 4 Kir6.2 subunits, there will be 1/16 channel with 0 mutant subunit, 4/16 channel with 1 mutant subunit, 6/16 channel with 2 mutant subunits, 4/16 channel with 3 mutant subunits, and 1/16 channel with all 4 mutant subunits.