Table 3.

Association between ERCC1 protein expression and clinical outcome

Cancer	Reference	n	Outcomea
NSCLC	Planchard et al90	188	0
	Koh et al89	130	0
	Zheng et al27	187	1
	Kang et al88	82	1
	Okuda et al38	55	(2)
	Okuda et al91	90	2
	Olaussen et al81	783	2
	Azuma et al84	67	2
	Fujii et al83	35	2
	Lee et al87	130	2
	Holm et al86	163	2; men P = 0.005, women P = 0.7
	Azuma et al85	34	2
	Lee et al82	50	2
	Ota et al80	156	2
	Reynolds et al79,b	69	2
	Vilmar et al78,b	264	2
	Wang et al77	214	2
	Taillade et al22	34	Biopsy vs tumor correlation
	Gomez-Roca et al (2009)	49	Primary vs metastasis
	Kang et al164	82	Primary vs metastasis
	Papay et al (2009)	17	Change after chemotherapy
	Besse et al (2010)c	761	Brain metastasis
HNSCC	Fountzilas et al31	37	0
	Koh et al89	80	0
	Handra-Luca et al97	96	2
	Jun et al98	45	2
	Fountzilas et al31,b	26	2

Notes:

^aOutcome for low ERCC1 expression, 0 = non significant changes, (1) = trend to worse, 1 = worse, (2) = trend to better, 2 = better;

^bprospective study;

^cretrospective analysis of prospective study.

Abbreviations: HNSCC, head and neck squamous cell carcinoma; NSCLC, non-small cell lung cancers.