Table 5.

Association between SNPs in XRCC1 and clinical outcome

Cancer	rs	SNPs	Alternate names	Reference	n	Outcomea
NSCLC	rs1799782	Arg194Trp	194 C > T; 194 R > W; 194 Arg > Trp; C26304T	Petty et al155,b	49	0
				Wang et al156	139	0
				Yuan et al157,b	199	0
				Yoon et al158	229	1
				Sun et al159,b	82	2
	rs25489	Arg280His	280 G > A; 280 R > H; 280 Arg > His	Yoon et al158	229	0
				Yuan et al157,b	199	(2)
	rs25487	Arg399Gln	G28152 A; 399 G > A; 399 R > Q; 399 Arg > Gln	Yoon et al158	229	0
				Petty et al155,b	49	0
				Sun et al159,b	82	0
				Yuan et al157	199	0
				Gurubhagavatula et al161,c	103	(1)
				Kalikaki et al57	119	1
				Yin et al67	257	1
				Wang et al156	139	1 (toxicity)
				Giachino et al160,b	203	2 (toxicity)
				De las Penas et al71,b	135	2
	rs3213245	−(77) T > C		Hsieh et al115	294	0
	rs1799782	Arg194Trp	194 C > T; 194 R > W; C26304T	Geisler et al162	190	0
				Csejtei et al145	108	1
	rs25487	Arg399Gln	G28152A; 399 G > A; 399 R > Q	Carles et al76	108	0
				Csejtei et al145	108	0
				Geisler et al162	190	2
				Quintela-Fandino et al74	103	2

Notes:

^aOutcome for variable allele, 0 = non significant, (1) = trend to worse, 1 = worse, (2) = trend to better, 2 = better;

^bprospective study;

^cretrospective analysis of prospective study.

Abbreviations: NSCLC, non-small cell lung cancers; rs, reference SNP; SNPs, single nucleotide polymorphisms.