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Influence of ABCB1 haplotype group on (A) methadone dose and (C) trough plasma (R)-methadone concentrations (Ctrough) among OPRM1 wild-type (118A/A) subjects; and OPRM1 118A > G genotype on (B) methadone dose and (D) Ctrough among ABCB1 AGCGC/AGTTT haplotype combination subjects.
Notes: Lines are medians. *P < 0.05, **P < 0.01 versus ABCB1 AGCGC/AGCGC haplotype group, †P < 0.05 OPRM1118A/A versus A/G,G/G genotype in ABCB1 AGCGC/AGTTT haplotype group.
