Table SC1.
Frequencies of ABCB1 haplotypesa and OPRM1 118A > G minor allele and genotypes in opioid-dependent methadone maintenance treatment patients
| ABCB1 haplotypeb | % (n) | OPRM1 c.118 A > G | % (n) |
|---|---|---|---|
| AGCGC | 29.8 (68) | MAF | 21.0 (50) |
| AGCGT | 9.6 (22) | A/A | 64.7 (77) |
| AGCTC | 3.1 (7) | A/G | 28.6 (34) |
| AGTGC | 4.8 (11) | G/G | 6.7 (8) |
| AACGC | 2.2 (5) | ||
| AGCTT | 5.7 (13) | ||
| AGTGT | 1.8 (4) | ||
| AGTTC | 2.6 (6) | ||
| AACTC | 0.4 (1) | ||
| GGCGT | 0.4 (1) | ||
| AGTTT | 32.0 (73) | ||
| GGTTT | 7.5 (17) |
Notes: Variant nucleotides in ABCB1 haplotypes are underlined.
a
Excluding subjects with PHASE call confidence probabilities less than 0.75.
b
Haplotypes consisting of 61A > G, 1199G > A, 1236C > T, 2677G > T, and 3435C > T single nucleotide polymorphisms of ABCB1.
Abbreviation: MAF, minor allele frequency.