Table 1.
Induction immunosuppression drugs
| Drug | Mechanism of action | Side effects |
|---|---|---|
| ATG/ALG | Complement mediated lysis Opsonization and clearance blockade of cell surface receptors |
Agranulocytosis Thrombocytopenia Cytokine release syndrome |
| Basiliximab (anti-CD25 antibody) | Blockade of IL-2 receptor | |
| Alemtuzumab | T and B lymphocyte depletion | Cytokine release syndrome |
| OKT3 | Complement-mediated lysis opsonization and clearance blockade of CD3 receptor | Cytokine release syndrome |
Abbreviations: ATG, antithymocyte globulin; ALG, antilymphocyte globulin; IL-2, interleukin-2; OKT3, monoclonal anti-CD3 antibody.