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. 2012 Dec 3;7(12):e50954. doi: 10.1371/journal.pone.0050954

Figure 4. Effect of NPB112 on hepatic and peripheral insulin sensitivity in DIO mice.

Figure 4

A. Fasting glucose levels in the hyperinsulinemic-euglycemic clamp studies before insulin infusion for mice treated with vehicle or NPB112 at 5.0 mg/kg. n = 5 per group. B. Hepatic insulin action as the percent suppression of basal hepatic glucose production before insulin infusion for mice treated with vehicle or NPB112 at 5.0 mg/kg. n = 5 per group. C. Hepatic insulin action as the percent suppression of clamp hepatic glucose production after insulin infusion at the rate of 15∼18 pmol/kg/min for mice treated with vehicle or NPB112 at 5.0 mg/kg. The clamp conditions were same as in A. n = 5 per group. D. Steady-state whole-body glucose infusion rate (GIR) during the last 30 min of the hyperinsulinemic-euglycemic clamp studies in mice treated with vehicle or NPB112 at 5.0 mg/kg. n = 5 per group. *, p<0.01 compared to control mice with vehicle.