Table 1. Pharmacokinetic parameters of NPB112 after single intravenous or intraperitoneal administration of 5 mg/kg NPB112 to Sprague-Dawley rats.
Intravenous administration(n = 5) | Intraperitoneal administration(n = 5) | |
Tmax (h) | NA | 24.0±0.0 |
Cmax (ug/ml) | NA | 28.4±3.5 |
AUClast (ug•h/ml) | 3354.2±802.9 | 2766.1±593.5 |
Clearance (l/h/kg) | 0.001±0.0004 | NA |
T1/2 (h) | 49.8±28.2 | 86.8±52.8 |
F (%) | NA | 103.3±45.5 |
NA: not applicable.