Table 2. Genotype/allele frequencies of five polymorphisms in apelin/APJ system between CAD patients and controls.
| Gene: polymorphism (rs number) (%) | Males (%) | Females (%) | |||||||
| Patients (n = 533) | Controls (n = 359) | ?2 | P | Patients (n = 461) | Controls (n = 349) | ?2 | P | ||
| apelin: | TT | −* | − | 44.06 | 45.38 | ||||
| rs3761581 | TG | − | − | 44.75 | 40.17 | 2.65 | 0.266 | ||
| GG | − | − | 11.19 | 14.45 | |||||
| G | 34.13 | 40.06 | 3.11 | 0.077 | 33.56 | 34.54 | 0.16 | 0.685 | |
| apelin: | AA | − | − | 43.5 | 44.35 | ||||
| rs56204867 | AG | − | − | 46.41 | 42.32 | 2.54 | 0.281 | ||
| GG | − | − | 10.09 | 13.33 | |||||
| G | 34.18 | 39.48 | 2.5 | 0.114 | 33.3 | 34.5 | 0.25 | 0.618 | |
| APJ: | GG | 59.92 | 58.79 | 60.05 | 58.38 | ||||
| rs7119375 | GA | 35.52 | 36.31 | 0.13 | 0.937 | 34.93 | 36.71 | 0.37 | 0.876 |
| AA | 4.56 | 4.9 | 5.02 | 4.91 | |||||
| A | 22.32 | 23.05 | 0.13 | 0.722 | 22.49 | 23.27 | 0.13 | 0.716 | |
| APJ: | CC | 60.12 | 58.79 | 60.05 | 58.38 | ||||
| rs10501367 | CT | 35.32 | 36.31 | 0.17 | 0.92 | 34.93 | 36.71 | 0.27 | 0.8758 |
| TT | 4.56 | 4.9 | 5.02 | 4.91 | |||||
| T | 22.22 | 23.05 | 0.16 | 0.686 | 22.49 | 23.27 | 0.13 | 0.716 | |
| APJ: | CC | 58.53 | 57.64 | 59.13 | 55.78 | ||||
| rs9943582 | CT | 34.92 | 35.73 | 0.07 | 0.966 | 33.01 | 35.55 | 0.91 | 0.635 |
| TT | 6.55 | 6.63 | 7.76 | 8.67 | |||||
| T | 24.01 | 24.5 | 0.05 | 0.817 | 24.32 | 26.45 | 0.93 | 0.335 | |
*
Because the gene encoding apelin is mapped on the X chromosome, genotype data are unavailable.