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. 2012 Dec 3;7(12):e50291. doi: 10.1371/journal.pone.0050291

Figure 6. THSG downregulates the expression of cleaved caspase-3 and upregulates the expression of p-ERK1/2, PPAR-γ and SIRT1 in diabetic ilea.

Figure 6

(A)Immunoreactive bands of cleaved caspase-3 using specific antibody. Actin was used as internal control. (B) Histogram representing the quantitative analysis of cleaved caspase-3 level normalized to actin protein. (C) Immunoreactive bands of ERK1/2 (both total and phosphorylated) using specific antibody. (D) Histogram representing the quantitative analysis of p-ERK1/2 normalized to total ERK1/2. (E) Immunoreactive bands of PPAR-γ using specific antibody. (F) Histogram representing the quantitative analysis of PPAR-γ level normalized to actin protein. (G) Immunoreactive bands of SIRT1 using specific antibody. (H) Histogram representing the quantitative analysis of SIRT1 level normalized to actin protein. n = 3 animals in each group. * P<0.05, ** P<0.01, vs DM group; # P<0.05, ## P<0.01, vs control group.