Figure 7. Pie charts showing results of immunohistochemical staining for HPV E4 proteins in productive cervical lesions caused by different HPV types using MoAb16E435–42, R18E453–60 or R58E423–30 antibodies.
In (A) cases are stratified according to CIN status. CIN1 is equivalent to LSIL, and in all cases where causality was known, type-specific E4 expression was apparent. Type-specific E4 expression was differentially distributed between lesions with an overall diagnosis of CIN2 or CIN3 depending on causative HPV type. All HPV18 CIN3 lacked E4 expression. In (B), the CIN2 and 3 groupings are pooled to produce the HSIL group. This group could be divided into two categories depending on whether E4 was expressed in the tissue section under examination.