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. 2012 Dec 3;7(12):e49707. doi: 10.1371/journal.pone.0049707

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© 2012 Collins et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Genetic makeup of iKras*p53* mice. (B) Experimental design: doxy was administered continuously, starting at weaning. Acute pancreatitis was induced within 72 hrs, then the animals were aged until they developed tumors. Kaplan-Meier survival curve. iKras*p53*, n = 25; iKras*p53^+/−, n = 9. Log-rank statistical analysis yielded a P value of 0.001. (C) Gross morphology pictures of a primary tumor and liver metastases. T: tumor, S: stomach, Sp: spleen, Int: intestine, L: liver (D). Histology of a moderately differentiated (top row) and an un-differentiated (bottom row) pancreatic tumor; liver and lung metastases. T: tumor. Scale bar 100 um.