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. 2012 Dec 3;7(12):e49707. doi: 10.1371/journal.pone.0049707

Figure 5. Pancreatic tumor relapse occurs following Kras* reactivation.

Figure 5

(A) Experimental design. (B) Identification of a large pancreatic tumor mass 22 weeks after Kras* activation. T: tumor, S: stomach, Sp: spleen, L: liver, G: gallbladder. (C) Images taken 1, 3 and 6 weeks following Kras* inactivation. Note the greatly reduced primary tumor mass and metastatic load. (D) Reactivation of Kras* results in rapid tumor relapse. (E) Histology of the primary tumor as well as metastases found in the liver and lung following tumor relapse show abundant phospho-ERK1/2 expression (insets). Scale bar 100 um (F) Tumor and total metastases volume at the indicated time points.