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. Author manuscript; available in PMC: 2013 Nov 19.
Published in final edited form as: Chem Res Toxicol. 2012 Oct 22;25(11):2542–2552. doi: 10.1021/tx300337j

Figure 6. Drosophila with RNAi Silencing of Ercc1 Display Expected Sensitivity Towards DNA-Modifying Agents with Known Modes of Action.

Figure 6

Time dependant survival of D. melanogaster after microinjection with vehicle or one of the following agents: cisplatin (panel A), chlorambucil (panel B), and 5-fluorouracil (panel C). Cisplatin and chlorambucil serve as positive verification for our assay, while 5-fluorouracil acts as a negative control. Each agent was injected into D. melanogaster in which Ercc1 expression was silenced (da-GAL4/UAS-Ercc1RNAi) and compared to flies with wild-type Ercc1 expression (da-GAL4/+). For each genotype, survival with injection of vehicle alone was also assessed.