Table 3.

Late-Life Body Mass Index measured at age 65 or older and risk of dementia, Alzheimer’s disease and vascular dementia in 2,798 participants of the CHS Cognition Study 1992-1999.

Dementia	Risk Factor	N	Adjusted for demographics1	p	Adjusted for demographics + CVD2	p
		Dementia/ Normal)	Hazard Ratio (95% Confidence Interval)		Hazard Ratio (95% Confidence Interval)
Total	BM (kg/m2)	480/2311	0.97 (0.95-.99)	.004	0.95 (0.92-0.98)	<.001
	BMI-categorical			.01		.005
	Underweight	31/85	1.62 (1.10-2.39)	.01	1.62 (1.02-2.64)	.04
	Normal	168/752	1.00 (reference)	---	1.00 (reference)	---
	Overweight	203/1004	0.93 (0.76-1.15)	.51	0.92 (0.72-1.18)	.50
	Obese	78/472	0.81 (0.61-1.07)	.13	0.63 (0.44-0.91)	.01
Alzheimer’s3	BMI (kg/m2)	245/2546	0.96 (0.93-0.99)	.009	0.95 (0.91-0.99)	.008
	BMI-categorical			.02		.05
	Underweight	17/99	1.53 (0.91-2.58)	.11	1.42 (0.74-2.70)	.29
	Normal	94/826	1.00 (reference)	---	1.00 (reference)	---
	Overweight	93/1114	0.76 (0.57-1.02)	.07	0.74 (0.52-1.05)	.10
	Obese	41/509	0.70 (0.48-1.03)	.07	0.58 (0.36-0.96)	.03
Vascular4	BMI (kg/m2)I	213/2570	0.98 (0.94-1.01)	.17	0.95 (0.91-0.99)	.02
	BMI-categorical			.15		.03
	Underweight	14/102	1.89 (1.06-3.37)	.03	2.15 (1.11-4.19)	.02
	Normal	67/853	1.00 (reference)	---	1.00 (reference)	---
	Overweight	98/1109	1.15 (0.84-1.57)	.39	1.20 (0.83-1.76)	.33
	Obese	34/516	0.98 (0.64-1.50)	.92	0.72 (0.41-1.27)	.26

¹adjusted for age, race, gender, years of education

²adjusted for age, race, gender, years of education + CRP + IL-6 + hypertension status + diabetes status + CHD + total cholesterol + AAI + smoking status + ApoE4

³Alzheimer’s disease without the presence of Vascular dementia using NINCDS criteria (possible or probable_

⁴Vascular dementia with or without the presence of AD using ADDTC criteria (possible or probable)..