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. Author manuscript; available in PMC: 2012 Dec 4.
Published in final edited form as: Mol Psychiatry. 2008 May 6;14(12):1095–1104. doi: 10.1038/mp.2008.48

Figure 3.

Figure 3

Interaction between interleukin-6 (IL-6) and 5-HTT genotype on depressive symptom scores. Symptoms are expressed as effect size (mean change from baseline ± s.e.m.) during 24 weeks of interferon-α (IFN-α) and ribavirin treatment. There was a significant gene–gene interaction (P = 0.02). (a) Within the CC genotype group, LL genotype subjects (n = 5) experienced significantly fewer depressive symptoms than the SS/SL genotype subjects (n =7) (P = 0.02). (b) Within the GG/GC genotype group, there was no difference in depressive symptoms experienced by the LL genotype subjects (n = 33) and the SS/SL genotype subjects (n = 39) (P = 0.1).