Table I.

Physicochemical Properties of the Drugs

Drug	Intrinsic S (mg/mL)	log P	Melting point (°C)a	pKa
Genistein	∼0.001b	3.04c	299	NA
Probucol	0.004–0.005 μg/mLd	10d	126	NA
Nifedipine	0.006e	3.17f	174	2.7g (base)
Indomethacin	0.002–0.007h,i	4.27j	155	4.50j (acid)

NA nonionizable over the practical pH range

^aManufacturer data

^bWu et al. (5)

^cRothwell et al. (6)

^dChristensen et al. (7)

^eCuratolo et al. (8)

^fLombardo et al. (9)

^gCalculated using Advanced Chemistry Development (ACD/Labs) Software v11.02

^hBergstrom et al. (10)

ⁱNokhodchi et al. (11)

^jLiu et al. (12)