Table II.
S. No. | Formulation code | Composition (% w/w) | Vesicular sizea (nm) | PDIa | % entrapment efficiencya | ||
---|---|---|---|---|---|---|---|
Lopinavir | Soya PC | Ethanol | |||||
1 | E1 | 0.5 | 1 | 30 | 225.6 ± 11.0 | 0.264 ± 0.016 | 48.3 ± 3.7 |
2 | E2 | 0.5 | 1 | 45 | 157.2 ± 07.5 | 0.212 ± 0.027 | 63.4 ± 4.1 |
3 | E3 | 0.5 | 1 | 60 | 178.2 ± 09.2 | 0.118 ± 0.006 | 39.2 ± 4.3 |
4 | E4 | 0.5 | 2 | 30 | 176.7 ± 18.6 | 0.146 ± 0.013 | 61.7 ± 3.8 |
5 | E5 | 0.5 | 2 | 45 | 112.8 ± 12.4 | 0.131 ± 0.008 | 79.6 ± 4.1 |
6 | E6 | 0.5 | 2 | 60 | 132.7 ± 07.6 | 0.223 ± 0.017 | 43.6 ± 4.7 |
7 | E7 | 0.5 | 3 | 30 | 164.5 ± 06.1 | 0.283 ± 0.023 | 50.3 ± 3.4 |
8 | E8 | 0.5 | 3 | 45 | 105.3 ± 03.9 | 0.244 ± 0.018 | 70.7 ± 4.4 |
9 | E9 | 0.5 | 3 | 60 | 123.8 ± 11.2 | 0.198 ± 0.011 | 33.7 ± 4.2 |
PDI polydispersity index, PC phosphatidylcholin
aValues represented as mean ± SD (n = 3)