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. 2012 Aug 21;13(4):1073–1083. doi: 10.1208/s12249-012-9829-9

Table II.

Values of SR from H1 to H6 and C Matrices at 2, 4, 8 and 24 h in Different Media

Batch 2 h 4 h 8 h 24 h
SR in demineralised water
H1 184.2 ± 4.2 251.9 ± 4.7 336.1 ± 3.2 485.8 ± 9.4
H2 149.3 ± 2.2 205.2 ± 2.5 268.3 ± 1.4 350.2 ± 3.4
H3 133.6 ± 2.9 176.6 ± 3.1 219.9 ± 1.7 280.0 ± 1.6
H4 78.1 ± 1.1 105.3 ± 1.2 117.2 ± 1.8 169.6 ± 8.4
H5 75.1 ± 0.9 90.0 ± 0.8 90.4 ± 1.5 99.5 ± 5.0
H6 57.9 ± 1.3 65.1 ± 0.9 52.1 ± 2.2 37.3 ± 4.1
C 21.0 ± 3.5 27.0 ± 9.6 21.3 ± 3.4 19.2 ± 2.4
SR in progressive pH medium
H1 177.5 ± 1.6 240.9 ± 9.4 314.2 ± 8.2 482.7 ± 4.3
H2 152.1 ± 3.2 202.7 ± 1.8 262.7 ± 3.6 368.5 ± 5.6
H3 136.4 ± 1.3 174.4 ± 3.3 217.3 ± 1.2 282.4 ± 4.8
H4 79.8 ± 1.6 101.1 ± 1.4 112.3 ± 0.8 183.2 ± 3.0
H5 71.1 ± 1.1 80.3 ± 1.5 82.6 ± 3.4 72.5 ± 3.4
H6 44.1 ± 1.2 49.1 ± 1.9 44.0 ± 2.0 21.9 ± 4.7
C −8.6 ± 0.6 −18.5 ± 2.2 −44.7 ± 5.6 −46.9 ± 5.5
SR in SGF
H1 174.9 ± 1.3 239.6 ± 8.7 314.5 ± 5.8 463.9 ± 5.2
H2 159.5 ± 1.8 217.3 ± 3.0 280.8 ± 7.0 357.3 ± 27
H3 138.3 ± 2.5 180.4 ± 1.2 226.7 ± 0.8 189.9 ± 37
H4 83.2 ± 2.2 109.1 ± 4.5 122.3 ± 9.8 −33.8 ± 5.3
H5 74.9 ± 0.8 72.6 ± 3.9 −36.5 ± 9.5
H6 53.6 ± 4.1 25.4 ± 2.8
C −24.4 ± 3.4 −61.8 ± 4.4 −96.8 ± 0.6 −98.1 ± 1.8
SR in SIF
H1 169.4 ± 6.4 237.6 ± 12 321.1 ± 8.6 509.3 ± 13
H2 142.5 ± 0.7 196.5 ± 1.6 252.6 ± 3.0 370.7 ± 8.3
H3 126.7 ± 2.4 167.1 ± 1.0 208.2 ± 2.5 230.4 ± 9.4
H4 76.8 ± 1.2 104.1 ± 1.4 124.1 ± 3.6 115.6 ± 7.5
H5 71.1 ± 0.5 85.9 ± 1.4 89.5 ± 1.4 97.8 ± 3.2
H6 54.7 ± 0.9 60.6 ± 0.9 54.6 ± 0.6 41.6 ± 0.9
C 15.0 ± 1.2 17.3 ± 1.4 12.1 ± 4.5 −4.5 ± 13.1

SR swelling ratio, SGF simulated gastric fluid with pepsin, SIF simulated intestinal fluid with pancreatin