Table II.
Values of SR from H1 to H6 and C Matrices at 2, 4, 8 and 24 h in Different Media
| Batch | 2 h | 4 h | 8 h | 24 h |
|---|---|---|---|---|
| SR in demineralised water | ||||
| H1 | 184.2 ± 4.2 | 251.9 ± 4.7 | 336.1 ± 3.2 | 485.8 ± 9.4 |
| H2 | 149.3 ± 2.2 | 205.2 ± 2.5 | 268.3 ± 1.4 | 350.2 ± 3.4 |
| H3 | 133.6 ± 2.9 | 176.6 ± 3.1 | 219.9 ± 1.7 | 280.0 ± 1.6 |
| H4 | 78.1 ± 1.1 | 105.3 ± 1.2 | 117.2 ± 1.8 | 169.6 ± 8.4 |
| H5 | 75.1 ± 0.9 | 90.0 ± 0.8 | 90.4 ± 1.5 | 99.5 ± 5.0 |
| H6 | 57.9 ± 1.3 | 65.1 ± 0.9 | 52.1 ± 2.2 | 37.3 ± 4.1 |
| C | 21.0 ± 3.5 | 27.0 ± 9.6 | 21.3 ± 3.4 | 19.2 ± 2.4 |
| SR in progressive pH medium | ||||
| H1 | 177.5 ± 1.6 | 240.9 ± 9.4 | 314.2 ± 8.2 | 482.7 ± 4.3 |
| H2 | 152.1 ± 3.2 | 202.7 ± 1.8 | 262.7 ± 3.6 | 368.5 ± 5.6 |
| H3 | 136.4 ± 1.3 | 174.4 ± 3.3 | 217.3 ± 1.2 | 282.4 ± 4.8 |
| H4 | 79.8 ± 1.6 | 101.1 ± 1.4 | 112.3 ± 0.8 | 183.2 ± 3.0 |
| H5 | 71.1 ± 1.1 | 80.3 ± 1.5 | 82.6 ± 3.4 | 72.5 ± 3.4 |
| H6 | 44.1 ± 1.2 | 49.1 ± 1.9 | 44.0 ± 2.0 | 21.9 ± 4.7 |
| C | −8.6 ± 0.6 | −18.5 ± 2.2 | −44.7 ± 5.6 | −46.9 ± 5.5 |
| SR in SGF | ||||
| H1 | 174.9 ± 1.3 | 239.6 ± 8.7 | 314.5 ± 5.8 | 463.9 ± 5.2 |
| H2 | 159.5 ± 1.8 | 217.3 ± 3.0 | 280.8 ± 7.0 | 357.3 ± 27 |
| H3 | 138.3 ± 2.5 | 180.4 ± 1.2 | 226.7 ± 0.8 | 189.9 ± 37 |
| H4 | 83.2 ± 2.2 | 109.1 ± 4.5 | 122.3 ± 9.8 | −33.8 ± 5.3 |
| H5 | 74.9 ± 0.8 | 72.6 ± 3.9 | −36.5 ± 9.5 | – |
| H6 | 53.6 ± 4.1 | 25.4 ± 2.8 | – | – |
| C | −24.4 ± 3.4 | −61.8 ± 4.4 | −96.8 ± 0.6 | −98.1 ± 1.8 |
| SR in SIF | ||||
| H1 | 169.4 ± 6.4 | 237.6 ± 12 | 321.1 ± 8.6 | 509.3 ± 13 |
| H2 | 142.5 ± 0.7 | 196.5 ± 1.6 | 252.6 ± 3.0 | 370.7 ± 8.3 |
| H3 | 126.7 ± 2.4 | 167.1 ± 1.0 | 208.2 ± 2.5 | 230.4 ± 9.4 |
| H4 | 76.8 ± 1.2 | 104.1 ± 1.4 | 124.1 ± 3.6 | 115.6 ± 7.5 |
| H5 | 71.1 ± 0.5 | 85.9 ± 1.4 | 89.5 ± 1.4 | 97.8 ± 3.2 |
| H6 | 54.7 ± 0.9 | 60.6 ± 0.9 | 54.6 ± 0.6 | 41.6 ± 0.9 |
| C | 15.0 ± 1.2 | 17.3 ± 1.4 | 12.1 ± 4.5 | −4.5 ± 13.1 |
SR swelling ratio, SGF simulated gastric fluid with pepsin, SIF simulated intestinal fluid with pancreatin