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. 2012 Aug 31;13(4):1091–1102. doi: 10.1208/s12249-012-9824-1

Table V.

Fitting In Vitro Drug Release Data of Different Batches According to Various Mathematical Models

Models Zero-order First-order Higuchi Korsmeyer–Peppas
Batches R 2 K o R 2 K F R 2 K H n R 2 K KP
FT-1 0.503 0.192 0.988 0.007 0.777 0.366 0.212 0.971 −0.115
FT-2 0.602 0.129 0.975 0.003 0.837 0.288 0.223 0.966 −0.192
FT-3 0.676 0.067 0.984 0.002 0.87 0.203 0.236 0.988 −0.268
FT-4 0.828 0.073 0.893 0.001 0.954 0.208 0.28 0.991 −0.364
FT-5 0.756 0.087 0.913 0.002 0.928 0.235 0.285 0.991 −0.320
FT-6 0.794 0.07 0.924 0.001 0.952 0.198 0.325 0.994 −0.417
FT-7 0.873 0.061 0.853 0.001 0.982 0.194 0.345 0.995 −0.481

Drug release exponents (n), Korsmeyer–Peppas release constant (K KP), correlation coefficient (R 2), zero-order release rate constants (K 0), first-order release rate constant (K F) of different models