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. Author manuscript; available in PMC: 2012 Dec 4.
Published in final edited form as: Cell Rep. 2012 Nov 8;2(5):1088–1095. doi: 10.1016/j.celrep.2012.10.006

Fig. 4.

Fig. 4

Model depicting different outcomes of template-switching during replication of an expandable repeat (see text for details). A. Progression of the replication fork through a long repetitive run. B. Switching from template to nascent strand during replication of the repeat. C. Extension of the leading strand along the repetitive Okazaki fragment. D. Leading strand switch to its original template and fork restart. E. Replication products containing repetitive loop-outs and gaps. F. Repeat expansions after the second round of replication. G. Post replicative formation of a double-strand break within the repeat and its repair leading to RIM. Complementary strands of the repeat are shown in green and red; 3′-ends of growing DNA chains are shown by arrows.