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. Author manuscript; available in PMC: 2014 Feb 1.
Published in final edited form as: Toxicol In Vitro. 2012 Aug 16;27(1):367–377. doi: 10.1016/j.tiv.2012.08.012

Figure 4. HEDS inhibits the function of redox-dependent DNA binding by Ku protein in glucose deprived cells.

Figure 4

Ku binding activity was compared after HEDS treatment of p53 wild type HCT116 (A) and p53 mutant HT29 (B) cells cultured in normal or glucose-deprived media. Mean for three to five independent experiments are shown with SD. A statistically significant reduction in Ku function in cells cultured in glucose-deprived media occurred after HEDS treatment (0.7 mM, *P<0.01; 3.3 mM, **P<0.001).