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. Author manuscript; available in PMC: 2014 Feb 1.
Published in final edited form as: Toxicol In Vitro. 2012 Aug 16;27(1):367–377. doi: 10.1016/j.tiv.2012.08.012

Figure 8. Glucose deprivation limits the rapid detoxification of HEDS by cellular bioreduction to mercaptoethanol (ME).

Figure 8

Culture media was assayed for ME by DTNB assay following HEDS exposure of p53 wild type HCT116 (A) and p53 mutant HT29 (B) cells cultured in normal or glucose-deprived media. Decreased HEDS conversion to ME occurred preferentially in glucose-deprived cells. Mean for three to five independent experiments are shown with SD. A statistically significant decrease in extracellular ME levels occurred independent of p53 status in glucose deprived cells (*P<0.01).